By Prof. Dr. med. Heinz Grefor Wieser (auth.), B. Sutter, O. Schröttner (eds.)
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Extra info for Advances in Epilepsy Surgery and Radiosurgery
There is clinical and experimental evidence of Gamma Knife capability to induce modulation in the neural system. Detailed mechanism of this modulation and dosemetric parameters enabling to induce such plasticity with no necrosis are still unknown. Subpial transection turning out actually to be quite disappointing, there is a specific rationale to test radiosurgery capability to treat EZ cortex while preserving the underlying function of this cortex when the functional risk for cortectomy is too high.
Elger CE, Schramm J (1993) Chirurgische Epilepsietherapie. Radiologe33: 165~171 8. Foerster 0, Penfield W (1930) Der Narbenzug am und im Gehirn bei traumatischer Epilepsie in seiner Bedeutung fUr das Zustandekommen der Anfiille und fUr die therapeutische Bekampfung derselben. Zschr Ges Neurol Psychiat 125: 475~ 572 9. Heikkinen ER, Heikkinen MI, Sotaniemi K (1992) Stereotactic radiotherapy instead of conventional Epilepsy surgery. Acta Neurochir 119: 159~160 10. Horsley V (1886) Brain-surgery. Br Med J 2: 670~674 II.
Critical features of the procedure are the strict sparing of vertically oriented incoming and outgoing neural elements, and minimal trauma to the cortical blood supply. Indeed, it has been shown that MST leaves normal function intact and only subtile and not disabling deficits may remain in some cases. Thus, MST permits an extention of surgical treatment to brain regions so far considered inoperable. Although improvement in seizure frequency is observed in a significant number of patients, the operation usua lly is not curative.
Advances in Epilepsy Surgery and Radiosurgery by Prof. Dr. med. Heinz Grefor Wieser (auth.), B. Sutter, O. Schröttner (eds.)