Download Canine and Feline Endocrinology and Reproduction by E. Feldman, R. Nelson PDF

By E. Feldman, R. Nelson

ISBN-10: 0721693156

ISBN-13: 9780721693156

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Additional resources for Canine and Feline Endocrinology and Reproduction

Example text

The relative roles of the direct baroreceptor input versus angiotensin mechanisms in the thirst response to extracellular dehydration have yet to be determined. Interaction of Plasma Osmolality and Blood Volume. Normal day-to-day regulation of water balance involves interaction between osmotic and volume stimuli. In the case of vasopressin secretion, decreases in extracellular fluid volume sensitize the release of vasopressin to a given osmotic stimulus. Thus for a given increase in plasma osmolality, the increase in plasma vasopressin concentration is greater in hypovolemic states than with normovolemia.

Glucocorticoids inhibit AVP release by a direct effect within the hypothalamus and/or neurohypophysis (Papanek and Raff, 1994; Papanek et al, 1997). This inhibition of AVP release is characterized by both an increase in osmotic threshold and a decrease in the sensitivity of the AVP response to increasing osmolality (Biewenga et al, 1991). Hyperadrenocorticism also causes resistance to the effect of AVP in the kidney, possibly through interference with the action of AVP at the level of the renal collecting tubules or direct depression of renal tubular permeability to water.

SATIATION OF THIRST. Dehydrated animals have a remarkable capacity to consume the appropriate volume of water to repair a deficit. It has been demonstrated that dogs deprived of water for various periods of time drink just the volume of water needed to meet the deficit within 5 minutes. All animals have this capacity, although some species take longer to ingest the required amount of fluid. Satiation of thirst in dogs and cats requires restoration of normal plasma osmolality and blood volume, with correction of plasma osmolality playing the major role.

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Canine and Feline Endocrinology and Reproduction by E. Feldman, R. Nelson

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