Download Cell death in the morphogenesis and teratogenesis of the by Dr. méd. Tomas Pexieder (auth.) PDF

By Dr. méd. Tomas Pexieder (auth.)

ISBN-10: 3540072705

ISBN-13: 9783540072706

ISBN-10: 3642661424

ISBN-13: 9783642661426

In spite of the continued growth of analysis within the fields of mobile and molecular biology, which has orientated many embryologists in the direction of molecular biology, no concrete clarification of morphogenesis has but been chanced on. the current nation of information of center improvement is characterised through an incredible discrepancy among the qualitative descriptions of what occurs at the organ point and the roughly quantitative info on subcellular and molecular occasions. it really is usually now not understood how cells shape tissues and the way tissues generate specific different types of an organ. In an try and fill the gaps we systematically studied within the interval 1968 to 1973 one of many normal yet quite missed morphogenetic mechanisms which integrates cells into tissues and organs-cell demise. just a small a part of our study on mobilephone loss of life within the improvement of chick, rat and human embryo hearts has as but been released in extenso. such a lot of it's been communicated in papers added at varied medical conferences. we wish to exploit the chance provided by way of Advances to give a syn­ thesis and integrative assessment of our effects. during this method the particular interval of discovery of the lifestyles of phone demise and of its morphogenetic function within the middle improvement come to an finish. This opens up the following part of our learn which is composed in reports of ways mobilephone demise is built-in with different morphogenetic mechanisms.

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Additional resources for Cell death in the morphogenesis and teratogenesis of the heart

Example text

In 1959 and 1960 these authors reported the occurrence of hemodynamically induced ventricular septal defects (VSD) in 92% of the embryos with experimentally induced pulmonary stenosis following the elimination of both right and left 6th aortic arches. 2% of live births and 18-22% of the clinical cases, Warkany, 1971), on the involvement of bulbar cushions in the formation of the ventricular septum (Rychter, 1959) and finally on the exi48 stence of a detailed study on the formal genesis of this kind of VSD (Rychter and Lemez, 1959).

In comparison with the values measured in ova the density of macrophages was significantly lower in all but the last two stages of the in vitro culture. d. d. revealed a significant difference at 40/16 hand 48/24 h points.

M l _ 7 macrophages. Arrows = isolated dying and dead cells. Scale marker =20 {Lm 32 25 ,/ ' . • tI / -. 27 Fig. 26. d. supravitally stained with Nile blue sulphate. Formaline-acetic acid, Mayer's hematoxylin-eosin. Scale marker = 20 [Lm Fig. 27. d. supravitally stained with Nile blue sulphate . M1- a macrophages, thick arrows = Nile blue sulphate stained myelin figures and residual bodies. Thin arrow = pre-necrotic cell. Scale marker = 10 [Lm 3 Advances in Anatomy. Vol. 51/3 33 neutral red there was no staining of healthy viable neighbouring cells.

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Cell death in the morphogenesis and teratogenesis of the heart by Dr. méd. Tomas Pexieder (auth.)

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