Download Chemoradiation in cancer therapy by Hak Choy PDF

By Hak Choy

ISBN-10: 158829028X

ISBN-13: 9781588290281

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45. Nigro ND, Vaitkevicius VK, Considine B Jr. Combined therapy for cancer of the anal canal: a preliminary report. Dis Colon Rectum 1974; 17(3):354–356. 46. Cummings BJ, Keane TJ, O’Sullivan B, et al. Epidermoid anal cancer: treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C. Int J Rad Onc Biol Phys 1991; 21(5):115–125. 47. Bartelink H, Roelofsen F, Eschwege F, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups.

PHARMACOLOGY OF FLUOROPYRIMIDINES The fluoropyrimidines as a group can affect the synthesis and function of both deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), and both of these two mechanisms 26 Saif and Diasio Fig. 3. Metabolism of the fluoropyrimidines: dTMP = deoxythymidine monophosphate, dUMP = deoxyuridine monophosphate, FdUDP = fluorodeoxyuridine diphosphate, FdUMP - fluorodeoxyuridine monophosphate, FdUTP = fluorodeoxyuridine triphosphate, FU-DNA= fluorouracildeoxyribonucleic acid, FUDP = fluorouracil diphosphate, FUMP = fluorouracil monophosphate, FU-RNA = fluorouracil-ribonucleic acid, FUTP = fluorouracil triphosphate.

The lack of incorporated uracil in these cells and the finding that this damage could also be caused by agents that did not cause dUTP elevation and dTTP depletion argued against the futile repair hypothesis (28). It was found that the fragment size range noted in these cells is similar to the estimated size of an individual replication unit, and it was proposed that the observed pattern of damage resulted from selective digestion of actively replicating DNA by an induced endonuclease activity.

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Chemoradiation in cancer therapy by Hak Choy


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