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By Rozen, P

ISBN-10: 0203214277

ISBN-13: 9780203214275

ISBN-10: 0203270916

ISBN-13: 9780203270912

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Additional resources for Colorectal cancer in clinical practice : prevention, early detection, and management

Example text

25 COLORECTAL CANCER IN CLINICAL PRACTICE how these biological changes come about, the timeframe over which they occur, and the mechanisms by which they might be regulated, especially by external influences. e. ‘initiation’. Surviving mutated cells proliferate, and if the mutations are biologically significant, then this eventually progresses through to cancer, driven to completion by promotional factors that in themselves do not necessarily damage DNA but do modify biological responsiveness. The initiation and promotion processes were conceived of as being strictly sequential.

21 COLORECTAL CANCER IN CLINICAL PRACTICE References (*Reviews and general articles) 1. 2. 3. 4. 5. 6. 7. 8. 22 Parkin DM, Pisani P, Ferlay J, Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 1999; 80: 827–41. *Potter JD, Epidemiologic, environmental and lifestyle issues in colorectal cancer. In: Prevention and Early Detection of Colorectal Cancer (Young GP, Rozen P, Levin B, eds). London: Saunders, 1996: 23–43. *Gertig DN, Hunter DJ, Genes and environment in the etiology of colorectal cancer.

15 This is discussed more fully in Chapter 7. Acromegaly This uncommon disorder is due to the pituitary gland secreting an excessive amount of growth hormone. 1). However, their individual overall contributions to the total cancer burden are small. One must not lose sight that of the two most important etiologies that we know about, one is acquired – diet and lifestyle – and the other is inherited – susceptibility. Prevention, therefore, is aimed at recognizing this susceptibility, correcting acquired risk habits, and detecting treatable neoplasia early on.

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Colorectal cancer in clinical practice : prevention, early detection, and management by Rozen, P


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