Download Current Diagnosis Treatment in Gastroenterology by Scott Friedman, Kenneth McQuaid, James Grendell PDF

By Scott Friedman, Kenneth McQuaid, James Grendell

A finished, clinically centred reference masking the entire vital gastrointestinal, hepatic, biliary, and pancreatic ailments. Now with thirteen thoroughly revised chapters, the second one variation gains up to date, inexpensive diagnostic methods and healing ideas.

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CLINICAL FEATURES ■■ Etiologies of hepatic granulomas include sarcoidosis (Figures 2-2A, B), infection (tuberculosis (Figure 2-2C), Mycobacterium avium intracellulare (Figure 2-2D), histoplasmosis), drugs (allopurinol), neoplasm (Hodgkin’s disease), primary biliary cirrhosis, extrahepatic inflammatory disease (inflammatory bowel disease) and foreign substance (mineral oil). Rarely, granulomas may occur in association with chronic hepatitis C. HISTOLOGIC FEATURES ■■ Type and location of granulomas are helpful clues to identify the etiology.

About one-third of autoimmune hepatitis cases have few or no plasma cells. ■■ Prominent mononuclear inflammation and hepatocyte dropout around a terminal hepatic venule may be seen in early phase (Figure 2-3C). ■■ Treated disease may present with normal histology or mild nonspecific chronic hepatitis. DIFFERENTIAL DIAGNOSIS ■■ Viral hepatitis ■■ Drug-induced liver injury (continued) Chapter 2: Chronic Hepatitis 25 Autoimmune Hepatitis (continued) A B FIGURE 2-3 FIGURE 2-3 (A) Autoimmune hepatitis with interface activity.

Continued) Chapter 2: Chronic Hepatitis 19 Chronic Viral Hepatitis (continued) B C FIGURE 2-1 FIGURE 2-1 (B) Chronic hepatitis C. Interface activity (piecemeal necrosis; arrow: an acidophil body). (C) Chronic hepatitis B with ground-glass hepatocytes. Glassy eosinophilic cytoplasm represents endoplasmic reticulum with hepatitis B antigen. The inclusion pushes the cytoplasmic contents and the nuclei eccentrically. 20 Chapter 2: Chronic Hepatitis D FIGURE 2-1 FIGURE 2-1 (D) Immunohistochemical staining for hepatitis B surface antigen (HBsAg, left) highlighting ground-glass hepatocytes.

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Current Diagnosis Treatment in Gastroenterology by Scott Friedman, Kenneth McQuaid, James Grendell


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