Download A History of Gastric Secretion and Digestion: Experimental by Horace W. Davenport PDF

By Horace W. Davenport

ISBN-10: 146147602X

ISBN-13: 9781461476023

This e-book examines the heritage of experimental examine in gastric secretion and digestion. the writer identifies the medical questions that experience occupied researchers and discusses the experiments that experience resulted in their options. via separating elements of experimental examine and tracing their evolution through the years, the publication presents gastric physiologists and gastroenterologists with a high-quality figuring out of the highbrow historical past in their box.

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Additional info for A History of Gastric Secretion and Digestion: Experimental Studies to 1975

Example text

Because at that time carbonic anhydrase was a popular object of study, and because its presence in parietal cells gave the first glimm er of light regarding the mechanism of acid secretion, I became known as the proprietor ofthe "carbonic anhydrase theory of acid secretion. " 107 1·0 • I • I. 0·8 •I • ·; • • 0·6 • . :: 0 2 4 6 8 10 12 Figure 1-16. Ordinates, carbonic anhydrase concentration in arbitrary units in slices of oxyntic mucosa of the cat. Abscissae, 1,000 oxyntic cells in adjacent slices of the oxyntic mucosa of the cat.

The relation between volume-rate of gastric secretion by dogs and the concentrations of "chloride fractions" in pooled samples. (From Gray JS, Bucher GR, Harman HH. The relationships between total acid and neutral chlorides of gastric juice. ) Table 1-2. 6 Source: Compiled from data in Gray JS, Bucher, GR, The composition ofgastric juice as a function of the rate of secretion. Am J Physiol 133:542-550, 1941. 17 18 / A HISTORY OF GASTRIC SECRETION AND DIGESTION Parietal cells, he said, secrete an isotonic solution ofHCI (or a mixture containing hydrobromic or hydroiodic ifbromide or iodide is in the blood), and this free acid first appears at the membrane forming the wall ofthe canaliculi.

At Rochester I told my story to E. S. Nasset, and he prepared dogs with Pavlov pouches for me. I was too ignorant of gastroenterology to know that Heidenhain pouches would be more useful and longer-lasting. I gave the dogs Iarge doses of sodium bromide, stimulated them to secrete with subcutaneous doses ofhistamine, and anlayzed the juice and concurrent samples of plasma by the same potentiometric method. Before I got very far, I received a Ietter from R. B. Fisher, my form er Supervisor at Oxford, proposing exactly the same experiment for exactly the same reason, the idea having come to him while invigilating Final Honour Schools examinations.

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A History of Gastric Secretion and Digestion: Experimental Studies to 1975 by Horace W. Davenport


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