By Rexford S. Ahima
ISBN-10: 1441916067
ISBN-13: 9781441916068
The weight problems epidemic has generated great curiosity lately as a result of the wide-ranging and critical opposed health and wellbeing and financial outcomes that encompass the matter. a lot realization has been fascinated by behaviors that bring about weight problems, particularly to over intake of energy-dense nutrition and to sedentary way of life. although, weight problems is an incredibly advanced with poorly outlined pathogenesis. due to drastically improved study within the zone, the invention of pathways within the mind and peripheral organs that mediate power homeostasis has supplied a framework for realizing the organic foundation of weight problems. Metabolic foundation of weight problems provides an incredible new measurement to the becoming literature on weight problems by way of supplying a finished evaluate of particularly how metabolic imbalance culminates in weight problems. built through a staff of professional authors, this crucial identify discusses the rules of strength stability, genetics of bodyweight legislation, hormones and adipokines, and metabolic pathways within the mind, liver, muscle and fats, to call simply a number of of the components lined. The e-book additionally examines the relationship among weight problems and diabetes, heart problems and different problems. present and destiny diagnostic and remedy suggestions also are reviewed. complete and well timed, Metabolic foundation of weight problems is a vital reference for realizing the burgeoning challenge of weight problems.
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25 g/day po (2–4 tabs po qd-bid) Contraindications/cautions: Acute surgical abdomen Bowel obstruction Fecal impaction Hypersensitivity to anthraquinone laxatives or to any of the ingredients Patients with nausea, vomiting, or other symptoms of appendicitis • Undiagnosed abdominal pain • • • • • Adverse effects: • Gastrointestinal: Abdominal pain, nausea, abdominal bloating, abdominal cramps, flatulence, diarrhea, pseudomelanosis coli, cathartic colon • Renal: Urine discoloration, nephritis • Other: Laxative abuse Chapter 4 / General GI Motility Disorders 41 Pregnancy category: C Lactation: Probably safe Relative cost: $ (generic available: $) Bisacodyl Brand name: Bisac-Evac, Bisco-Lax, Dulcolax, Dacodyl Class: Stimulant laxatives Manufacturer: Dulcolax—Boehringer-Ingelheim Consumer Healthcare, Bisacodyl—generic Dosage: Constipation: 5–15 mg po once daily up to 30 mg/day or 10 mg suppository pr once daily Contraindications/cautions: • Hypersensitivity to drug • Nausea, vomiting • Intestinal obstruction Adverse effects: • Gastrointestinal: Abdominal colic, abdominal discomfort, diarrhea, Proctitis (with suppository use), atony of colon Pregnancy category: C Lactation: Safety unknown Relative cost: $ (Generic available: $) Castor Oil Brand name: Alphamul, Emulsoil, Neoloid, Purge Class: Stimulant laxatives Manufacturer: Generic Dosage: Constipation: 15–60 mL po once daily Contraindications/cautions: Hypersensitivity to drug Intestinal obstruction Acute abdominal pain, nausea, vomiting Symptoms of appendicitis • Pregnancy • • • • Adverse effects: • Gastrointestinal: Abdominal pain, nausea, vomiting • Musculoskeletal: Cramps 42 Rezaizadeh and Olson Pregnancy category: X Lactation: Possibly unsafe Relative cost: $ (generic available: $) Lubiprostone Brand name: Amitiza Class: Chloride-channel activator, laxative Manufacturer: Sucampo Pharmaceuticals, Inc.
Dosage: • Gastroparesis: 10 mg tid-qid Contraindications: • Hypersensitivity to domperidone products • GI hemorrhage/obstruction • Concomitant use of ketoconazole Adverse effects: • CNS: Headache • GI: Xerostomia • Cardiovascular: May prolong QT interval Pregnancy category: Not classified Lactation: Probably safe Relative cost: $$ Cisapride Brand name: Propulsid Manufacturer: Janssen Pharmaceutica Withdrawn from US market March 2000. Available for compassionate use only. For more information contact manufacturer.
Contraindications/cautions: •• Hypersensitivity to budesonide • Caution in patients with TB, HTN, DM, osteoporosis, peptic ulcer disease, glaucoma, cataracts Adverse effects (generally well-tolerated with fewer side effects than corticosteroids): •• Gastrointestinal: Nausea, abdominal pain, vomiting, dyspepsia •• Dermatologic: Easy bruising, acne •• Respiratory infection • Neurological: Dizziness, headache Drug interactions: • Live vaccines: Inadequate immunological vaccine response and increased risk of disseminated infection Pregnancy category: C Lactation: No data from controlled trials Relative cost: $$$$ Hydrocortisone Retention Enema Brand name: Cortenema Manufacturer: ANI Pharmaceuticals, Inc Dosage: Ulcerative colitis, especially distal forms: 1 enema pr nightly for up to 21 day or until patient goes into remission Contraindications/cautions: •• Hypersensitivity to hydrocortisone •• Systemic fungal infections • Immediate or early post-op period after ileocolostomy 50 Rezaizadeh and Olson Adverse effects: •• Local pain or burning •• Rectal bleeding • Other possible systemic effects of glucocorticoids including: –– Gastrointestinal: Nausea, vomiting, dyspepsia, appetite change –– Cardiovascular: Hypertension –– Endocrine metabolic: Body fluid retention, decreased body growth, hypernatremia, osteoporosis, hypercortisolism, hyperglycemia, primary adrenocortical insufficiency –– Immunologic: Immunosuppression –– Dermatologic: Atrophic condition of skin, impaired wound healing –– Psychiatric: Depression, euphoria, mood swings, anxiety –– Ophthalmic: Cataract, glaucoma Drug interactions: • May have increased risk of infection if used in conjunction with other immunosuppressants Pregnancy category: C Lactation: No data from controlled trials Relative cost: $$$$ Immunomodulatory Therapies For suggested use, see algorithms at end of the chapter.
Metabolic Basis of Obesity by Rexford S. Ahima
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