By Antonio Cardesa, Pieter J. Slootweg, Nina Gale, Alessandro Franchi
ISBN-10: 3662496704
ISBN-13: 9783662496701
ISBN-10: 3662496720
ISBN-13: 9783662496725
This e-book offers a finished description of the pathology of the pinnacle and neck area, concentrating particularly on these pathologic entities which are precise to or attribute of the pinnacle and neck. the hot version keeps the 10 chapters of the 1st variation, all up-to-date and more advantageous, and also comprises seven completely new chapters and a extra targeted topic index. The variety of illustrations has been considerably elevated, and numerous lesions absent within the unique variation were incorporated. all through, recognition is paid to correlation of pathology with epidemiology, medical gains, pathogenesis, and molecular genetics. Differential analysis is addressed, and data can also be supplied on staging, analysis, and remedy. The authors contain most suitable specialists within the box, a few of whom are senior individuals of the operating team on Head and Neck Pathology of the eu Society of Pathology.
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Sample text
A few cases of ASC, particularly those occurring at sites with a known high prevalence of HPV, are probably related to HPV infection. Masand et al. described one case of ASC from the nasal mucosa and two cases of ASC from the oropharynx, which have been found to harbour high-risk HPV E6 and E7, suggesting active transcription with detectable E6 and E7 and overexpression of p16 [288]. The histogenesis of ASC has not yet been completely elucidated. Some authors have suggested an origin in the salivary and/or mucoserous glands, while others favour a surface epithelial derivation or a combined glandular and surface epithelial derivation [286].
1989;14:333–42. 31. Laryngeal papillomas: the epidemiology in a Danish subpopulation 1965-1984. Clin Otolaryngol. 1990;15:125–31. Kashima HK, Shah F, Lyles A, Glackin R, Muhammad N, Turner L, et al. A comparison of risk factors in juvenile-onset and adult-onset recurrent respiratory papillomatosis. Laryngoscope. 1992;102:9–13. Recurrent respiratory papillomatosis. Pediatr Clin N Am. 1996;43:1385–401. Papilloma/papillomatosis. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. Pathology & genetics.
The 3q26-28 amplicon This amplicon includes three putative oncogenes frequently amplified in HNSCC: phosphatidylinositol- 4,5-bisphosphate 3-kinase (PIK3CA) gene, tumor protein p63 (TP63) gene and SRY (sex- determining region Y)-box 2 gene (SOX2). PIK3CA encodes the p110α catalytic subunit of phosphoinositide-3 kinase (PI3K). PIK3CA mutations and amplification occur in HNSCC. Gains and amplifications at 3q26 are important in the transition between preinvasive and invasive lesions [356, 357]. TP63 produces six different protein products, with ΔNp63 as the predominant form in the head and neck SCC, in which it can have a putative oncogenic function promoting cell proliferation [358, 359].
Pathology of the Head and Neck by Antonio Cardesa, Pieter J. Slootweg, Nina Gale, Alessandro Franchi
by Kenneth
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