By George Y. Wu (eds.)
ISBN-10: 3319333151
ISBN-13: 9783319333151
ISBN-10: 3319333178
ISBN-13: 9783319333175
This re-creation is a entire, but concise textual content that gives present remedy protocols and useful pharmacological info for GI affliction. every one bankruptcy addresses a particular GI affliction or situation and gives an inventory of all brokers on hand for that , together with all model and customary names, symptoms, contraindications, lactation and being pregnant details, doses, routes of management, length, and relative expense. The textual content can be supplemented with tables, algorithms, and key references.
Written via specialists within the box, Pocket guide of GI Pharmacotherapeutics, moment Edition is a beneficial and conveyable source of use to a person fascinated by the therapy of sufferers with GI disease.
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Extra resources for Pocket Handbook of GI Pharmacotherapeutics
Example text
25 g/day po (2–4 tabs po qd-bid) Contraindications/cautions: Acute surgical abdomen Bowel obstruction Fecal impaction Hypersensitivity to anthraquinone laxatives or to any of the ingredients Patients with nausea, vomiting, or other symptoms of appendicitis • Undiagnosed abdominal pain • • • • • Adverse effects: • Gastrointestinal: Abdominal pain, nausea, abdominal bloating, abdominal cramps, flatulence, diarrhea, pseudomelanosis coli, cathartic colon • Renal: Urine discoloration, nephritis • Other: Laxative abuse Chapter 4 / General GI Motility Disorders 41 Pregnancy category: C Lactation: Probably safe Relative cost: $ (generic available: $) Bisacodyl Brand name: Bisac-Evac, Bisco-Lax, Dulcolax, Dacodyl Class: Stimulant laxatives Manufacturer: Dulcolax—Boehringer-Ingelheim Consumer Healthcare, Bisacodyl—generic Dosage: Constipation: 5–15 mg po once daily up to 30 mg/day or 10 mg suppository pr once daily Contraindications/cautions: • Hypersensitivity to drug • Nausea, vomiting • Intestinal obstruction Adverse effects: • Gastrointestinal: Abdominal colic, abdominal discomfort, diarrhea, Proctitis (with suppository use), atony of colon Pregnancy category: C Lactation: Safety unknown Relative cost: $ (Generic available: $) Castor Oil Brand name: Alphamul, Emulsoil, Neoloid, Purge Class: Stimulant laxatives Manufacturer: Generic Dosage: Constipation: 15–60 mL po once daily Contraindications/cautions: Hypersensitivity to drug Intestinal obstruction Acute abdominal pain, nausea, vomiting Symptoms of appendicitis • Pregnancy • • • • Adverse effects: • Gastrointestinal: Abdominal pain, nausea, vomiting • Musculoskeletal: Cramps 42 Rezaizadeh and Olson Pregnancy category: X Lactation: Possibly unsafe Relative cost: $ (generic available: $) Lubiprostone Brand name: Amitiza Class: Chloride-channel activator, laxative Manufacturer: Sucampo Pharmaceuticals, Inc.
Dosage: • Gastroparesis: 10 mg tid-qid Contraindications: • Hypersensitivity to domperidone products • GI hemorrhage/obstruction • Concomitant use of ketoconazole Adverse effects: • CNS: Headache • GI: Xerostomia • Cardiovascular: May prolong QT interval Pregnancy category: Not classified Lactation: Probably safe Relative cost: $$ Cisapride Brand name: Propulsid Manufacturer: Janssen Pharmaceutica Withdrawn from US market March 2000. Available for compassionate use only. For more information contact manufacturer.
Contraindications/cautions: •• Hypersensitivity to budesonide • Caution in patients with TB, HTN, DM, osteoporosis, peptic ulcer disease, glaucoma, cataracts Adverse effects (generally well-tolerated with fewer side effects than corticosteroids): •• Gastrointestinal: Nausea, abdominal pain, vomiting, dyspepsia •• Dermatologic: Easy bruising, acne •• Respiratory infection • Neurological: Dizziness, headache Drug interactions: • Live vaccines: Inadequate immunological vaccine response and increased risk of disseminated infection Pregnancy category: C Lactation: No data from controlled trials Relative cost: $$$$ Hydrocortisone Retention Enema Brand name: Cortenema Manufacturer: ANI Pharmaceuticals, Inc Dosage: Ulcerative colitis, especially distal forms: 1 enema pr nightly for up to 21 day or until patient goes into remission Contraindications/cautions: •• Hypersensitivity to hydrocortisone •• Systemic fungal infections • Immediate or early post-op period after ileocolostomy 50 Rezaizadeh and Olson Adverse effects: •• Local pain or burning •• Rectal bleeding • Other possible systemic effects of glucocorticoids including: –– Gastrointestinal: Nausea, vomiting, dyspepsia, appetite change –– Cardiovascular: Hypertension –– Endocrine metabolic: Body fluid retention, decreased body growth, hypernatremia, osteoporosis, hypercortisolism, hyperglycemia, primary adrenocortical insufficiency –– Immunologic: Immunosuppression –– Dermatologic: Atrophic condition of skin, impaired wound healing –– Psychiatric: Depression, euphoria, mood swings, anxiety –– Ophthalmic: Cataract, glaucoma Drug interactions: • May have increased risk of infection if used in conjunction with other immunosuppressants Pregnancy category: C Lactation: No data from controlled trials Relative cost: $$$$ Immunomodulatory Therapies For suggested use, see algorithms at end of the chapter.
Pocket Handbook of GI Pharmacotherapeutics by George Y. Wu (eds.)
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