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By Dr. A.B.R. Thomson

This ebook offers a systematic foundation for scientific perform in Gastroenterology and Hepatology.

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Extra resources for Scientific Basis for Clinical Practice in Gastroenterology and Hepatology [Paperback] [2012]

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2008 ACG Annual Postgraduate course Book: page 148. 148 Second Edition, Boron Walter F. and Boulpaepemile L. 9, page 1041. R Thomson 14  Ghrelin o Food releases ghrelin, glucagon, GLP-1 (glucagon-like peptide-1), gastrin-releasing peptide (GRP), SS, peptide YY (PYY), and CCK* (cholecystokinin). o These cause short-term  intake. o Gastric ghrelin is the only GI hormone which stimulates food intake. o Ghrelin acts on both the brainstem solitary nucleus (NTS) as well as on the hypothalamus. o Ghrelin released from the gastric mucosa from the presence of food binds to GHSR in arcuate nucleus (ARC) and vagal afferents to ↓ food intake.

Problem: Draw a picture of the absorption of water from along the intestinal tract where the person is eating, or just drinking water. CLINICAL PHYSIOLOGICAL CORRELATION – Iron Metabolism Background: In HFE-related hereditary hemochromatosis, loss of functional HFE protein leads to aberrant hepatocellular sensing of plasma iron, with inappropriately low levels of hepcidin, diminished macrophage iron stores, and inappropriately greater duodenal iron absorption. Problem: Draw a picture of the absorption of dietary iron by the duodenal enterocyte, and the role of both the intestine and the liver in causing hereditary hemochromatosis.

R Thomson 10 CONTROL OF FOOD INTAKE Abbreviations: AGRP, agouti-related protein; CCK, cholecystokinin; DMN, dorsomedial hypothalamic nucleus; LHA, lateral hypothalamic area; NTS, nucleus tractus solitarus; NPY, neuropeptide Y; POMC, proopiomelancortin; PVN, paraventricular nucleus; VMN, venteromedial nucleus Adapted from: Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. R Thomson 11 Networks Involved in the Control of Food Intake  Mouth- oropharyngeal reflexes are stimulated by chewing and swallowing, and may reduce food intake after a certain threshold.

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Scientific Basis for Clinical Practice in Gastroenterology and Hepatology [Paperback] [2012] by Dr. A.B.R. Thomson


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