Download Signaling pathways in liver diseases by Jean-Francois Dufour, Pierre-Alain Clavien PDF

By Jean-Francois Dufour, Pierre-Alain Clavien

ISBN-10: 1118663357

ISBN-13: 9781118663356

ISBN-10: 1118663365

ISBN-13: 9781118663363

ISBN-10: 1118663381

ISBN-13: 9781118663387

ISBN-10: 111866339X

ISBN-13: 9781118663394

Signaling Pathways in Liver ailments, 3rd Edition back offers hepatologists and hepatology researchers with knowledgeable assessment of the advanced and novel cellular/extracellular signaling pathways within the liver, and their position in liver illnesses. the previous couple of years have noticeable a large number of advancements during this box, which in flip have ended in new possibilities for cutting edge remedies; notwithstanding, the intricacy of those pathways and their interactions proceed to supply a true problem for clinicians. This amazing e-book compiles the rising wisdom right into a unmarried specialist source, cataloguing and organizing it into an available and comprehensible format.

With elevated specialise in the comprehension of mobile mechanisms concerned about steatohepatitis, cirrhosis, and liver tumors, which has resulted in alterations within the administration of those ailments, this re-creation additionally sees the creation of intriguing new chapters on key rising parts such as:

  • Autophagy
  • Notch Pathway
  • P13K/PTEN Signaling in Liver Diseases
  • Sirtuins
  • Hepcidin and Iron
  • Epigenetic law of Hepatic Stellate Cells and Liver Fibrosis
  • Oxidative tension and Signaling within the Liver.

Professors Dufour and Clavien have assembled an all-star solid of bankruptcy authors, each one of whom has supplied transparent and acceptable illustrations to augment the textual content, with a key issues field providing a concise and convenient precis. Self-assessment questions and solutions let the reader to check their very own knowledge.

Signaling Pathways in Liver disorder, 3rd Edition is the ideal academic and reference instrument to bridge the knowledge alternate among the laboratory, the scientific ward, and the working room, and an important software for the modern day hepatologist.

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Extra info for Signaling pathways in liver diseases

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Two plasma membrane receptors have been identified: Patched 1 and 2 (PTC1 and PTC2). Hedgehog signaling is essentially an autocrine/ p­aracrine system in which Hh ligands are synthesized as a 40 kDa precursor and proteolytically processed to a smaller 25 kDa N‐terminal fragment, which is p­ almitoylated and conjugated to one cholesterol m­olecule before secretion [146]. The ligand then binds to Patched receptors on the membrane of the secretory cell or neighbor cells. This binding promotes the inter­ action of Patched with a second transmembrane p­rotein (Smoothened – SMO) on the surface of the receiving cell.

70 Glaser SS, Rodgers RE, Phinizy JL, et al. Gastrin inhibits secretin‐induced ductal secretion by interaction with specific receptors on rat cholangiocytes. Am J Physiol 1997;273:G1061–1070. 71 Tietz PS, Alpini G, Pham LD, et al. Somatostatin inhibits secretin‐induced ductal hypercholeresis and exocytosis by cholangiocytes. Am J Physiol Gastrointest Liver Physiol 1995;269:G110–118. 72 Marzioni M, Glaser S, Francis H, et al. Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendo­ crine hormone serotonin.

Moreover, glybenclamide stimu­ lates ductular secretion by activation of Na+‐K+‐2Cl– cotransport, rather than via mechanisms involving cAMP or Cai2+ [163]. The cAMP signaling pathway is important for the r­egulation of cholangiocyte proliferation. Cholangiocytes undergo proliferation in response to events such as bile duct ligation and partial hepatectomy [164–166]. Under such conditions, proliferation of cholangiocytes is a­ssociated with increases in expression of the secretin receptor, secretin‐stimulated cAMP levels, and ductal secretion [17,56,165,167].

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Signaling pathways in liver diseases by Jean-Francois Dufour, Pierre-Alain Clavien


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