By Chandrashekhar Gandhi PhD, Massimo Pinzani MD PhD FRCP
ISBN-10: 0128001348
ISBN-13: 9780128001349
Stellate Cells in well-being and Disease is a complete reference delivering the main up to date wisdom and views at the functionality of stellate cells affecting the liver and different organs.
The textual content offers accomplished insurance in their already proven position in hepatic fibrosis in addition to the more recent rising facts for stellate phone participation within the liver telephone (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver melanoma.
Chapters describe either animal and human study and the relevance of findings from animal examine to human pathophysiology, and in addition comprise sections on destiny instructions so one can be of specific curiosity to uncomplicated and medical researchers engaged on liver fibrosis, hepatic biology, and pathobiology.
- Presents insurance of the mechanisms of liver fibrosis with stellate cells as a objective for therapy.
- Shows stellate cells as a massive player in hepatic immunobiology, together with transplantation immunology.
- Key illustrations exhibit the phenotypical adjustments in stellate cells in situ and tissue tradition, their interactions with different phone varieties, signaling pathways and display the services and roles of stellate cellphone in pathological approaches.
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Additional info for Stellate Cells in Health and Disease
Example text
Measurement of portal pressure and its role in the management of chronic liver disease. Semin Liver Dis 2006;26:348–62. [38] Mehal WZ, Iredale J, Friedman SL. Scraping fibrosis: expressway to the core of fibrosis. Nat Med 2011;17:552–3. [39] Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner DA. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology 2004;126:529–40. [40] Mazzocca A, Sciammetta SC, Carloni V, et al. Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells.
The diagnosis of fatty liver disease can be suspected initially on the basis of abnormally high aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) levels and ultrasonographic findings of fatty liver [6]. The increasing burden of NAFLD and the current lack of effective treatments to halt or reverse disease progression in patients with NASH have led to intense investigation into the basic mechanisms involved in the development and progression of the disease. The most accepted concept outlining the pathogenesis of NAFLD implies the occurrence of parallel events (hits) that involve a complex interaction and crosstalk Hepatic Fibrosis: A Global Clinical Problem among environmental factors, host genetics, and gut microflora [28].
7] De MS, Seki E, Uchinami H, et al. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 2007;132(5):1937–46. [8] Friedman SL, Rockey DC, McGuire RF, et al. Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture. Hepatology 1992;15(2):234–43. [9] Ichikawa S, Mucida D, Tyznik AJ, et al. Hepatic stellate cells function as regulatory bystanders. J Immunol 2011;186(10):5549–55.
Stellate Cells in Health and Disease by Chandrashekhar Gandhi PhD, Massimo Pinzani MD PhD FRCP
by Jason
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