By E. Neil Moore D.V.M., Ph.D, Joseph F. Spear Ph.D. (auth.), J. Morganroth M.D., E. Neil Moore D.V.M., Ph.D. (eds.)
ISBN-10: 146133876X
ISBN-13: 9781461338765
ISBN-10: 1461338786
ISBN-13: 9781461338789
In Harch of 1980, we equipped the 1st symposium on easy methods to assessment new antiarrhythmic brokers during which the contributors integrated individuals of the Cardio-Renal department of the nutrition and Drug management, educational investigators from the us and overseas and administrators and imple mentors of pharmacological study representing the pharmaceutical undefined. by way of bringing jointly all 3 components, it was once was hoping that greater verbal exchange and lower than status may occur to extra quickly convey new cardiac brokers to the yankee public. This objective was once vital when you consider that a slightly constrained variety of antiarrhythmic brokers have been and are presently to be had to regard sufferers with such problems within the usa. those brokers are wanted not just for the therapy of sufferers with sustained ventricular tachyarrhythmias which produce life-threatening hemodynamic effects but in addition and in reality extra probably vital as a prophylactic degree within the excessive danger sufferer topic to unexpected cardiac dying. This ebook represents the court cases of the 3rd of those Symposiums whose objective was once to judge the scientific learn method and versions utilized in the assessment of ne" antiarrhythmic brokers for not just acute healing inter vention but additionally for the prophylaxis of unexpected cardiac dying. moreover, new units have advanced over the last few years that could discover and deal with life-threatening cardiac arrhythmias and the evaluate of efficacy and security of those units is detailed.
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Additional info for Sudden Cardiac Death and Congestive Heart Failure: Diagnosis and Treatment: Proceedings of the Symposium on New Drugs and Devices, held at Philadelphia, PA, October 26 and 27, 1982
Example text
For example, a drug that prolonged refractoriness by delaying repolarization might exert effects similar to another drug that caused use-dependent block of fast channels and had an appropriate time constant for the disappearance of use-dependent block. When more has been learned about the nature of drug interaction with specific ion channels through the use of the patch-clamp, a meaningful classification should be possible. Until that data is available, it would 38 be useful to at least include a description of the kinetics of use dependent block for drugs that interact with either fast inward or slow inward channels.
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6. 7. 8. Hondeghem LM, Katzung BG. 1977. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta 472:373-398. Hariman RJ, Hoffman BF, Naylor RE. 1980. Electrical activity from the sinus node region in conscious dogs. Circ rtes 47:775-791. Hoffman BF, Cranefield PF. 1969. Electrophysiology of the Heart. Blakiston, New York. Karagueuzian HS, Fenoglio JJ, Weiss MB, Wit AL. 1979. Protracted ventricular tachycardia induced by premature stimulation of the canine heart after coronary artery occlusion and reperfusion.
Sudden Cardiac Death and Congestive Heart Failure: Diagnosis and Treatment: Proceedings of the Symposium on New Drugs and Devices, held at Philadelphia, PA, October 26 and 27, 1982 by E. Neil Moore D.V.M., Ph.D, Joseph F. Spear Ph.D. (auth.), J. Morganroth M.D., E. Neil Moore D.V.M., Ph.D. (eds.)
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