By Novartis Foundation
ISBN-10: 0470843462
ISBN-13: 9780470843468
This ebook reports and discusses the newest advances within the knowing of the molecular genetic pathways of intercourse selection, with certain emphasis on vertebrates. Inter alia, assurance comprises the genetics and biochemistry of mammalian intercourse decision, comparisons with different modes of intercourse decision, and attention of the biology of sexual improvement and of the evolution of sex-determining mechanisms. by means of bringing jointly a global and interdisciplinary staff of specialists whose paintings is concentrated on many various facets of the matter, the publication stories a lot new and fascinating paintings during this region and serves to spot and stimulate promising new study instructions.
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Extra info for The Genetics and Biology of Sex Determination
Example text
We have not been looking at that level of regulation, and we should consider it more carefully. Vilain: We know that 3’ UTR deletion in humans results in XY sex reversal. Capel: And it also seems to be required in the mouse for e⁄cient sex reversal. I’m convinced that this is an important element of the gene. For all we know, the RNA is localized through the 3’ UTR, and where it is localized it is translated. Perhaps this creates a localized high concentration. I’m just suggesting that there could be many elements of regulation here that we are not in touch with.
Clinical management of these conditions critically depends on a precise understanding of their pathophysiology. Until recently, only transcription factors such as SRY, SOX9, DAX1, WT1 and SF1 were known to be responsible for abnormal gonadal development and sexual ambiguity. Gonadal dysgenesis may be isolated, as in the case of SRY mutations, or associated with abnormal development of other organs, such as bone or adrenals, consistent with the spatial expression pro¢le of the disrupted genes (SOX9 or SF1).
Perhaps this creates a localized high concentration. I’m just suggesting that there could be many elements of regulation here that we are not in touch with. Swain: And WT1 might be involved in this process. Goodfellow: Has any more work been done in those species where there has been Sry ampli¢cation, looking for potentially co-ampli¢ed genes? The rat has 20 copies of Sry, although it is not clear how many of these are active. Clearly, if one gene is ampli¢ed, another related gene might also be ampli¢ed.
The Genetics and Biology of Sex Determination by Novartis Foundation
by Steven
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