By George D. Snell
ISBN-10: 012653750X
ISBN-13: 9780126537505
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A s i n t h e c a s e of t h e Y - l i n k e d l o c u s , t h e r e are variations in rejection times of g r a f t s b e a r i n g t h e X - l i n k e d h i s t o i n c o m p a t i b i l i t y , so t h a t m o d i f y i n g f a c t o r s h a v e t o b e p o s t u l a t e d ( B a i l e y , 1964 ) . V I I . N u m b e r of A l l e l e s at H i s t o c o m p a t i b i l i t y L o c i I t is c o m m o n p l a c e i n g e n e t i c s t h a t m o s t l o c i h a v e m u l t i p l e alleles. D e s p i t e t h e t e c h n i c a l difficulties of s t u d y i n g h i s t o c o m p a t i b i l i t y l o c i , w e c a n n o w s a y w i t h c o n f i d e n c e t h a t t h e y a r e n o e x c e p t i o n .
B y s i m i l a r t e s t s it w a s s h o w n t h a t B I O . L P differs f r o m B I O n o t o n l y b y H-3, b u t a l s o b y a s e c o n d l o c u s , H-13, b o t h linked to agouti. The B 6 X C c r o s s , u s e d b y B a i l e y ( 1 9 7 1 , 1 9 7 5 ) t o p r o d u c e a g r o u p of B 6 . C c o n g e n i c r e s i s t a n t l i n e s , s e g r e g a t e d for a n u m b e r of m a r k e r g e n e s t h a t t u r n e d o u t t o b e l i n k e d w i t h h i s t o c o m p a t i b i l i t y loci ( B a i l e y , 1975, a n d personal c o m m u n i c a t i o n ) .
B 6 DBA/2 H*H* HdH* H H XH H b of Probability d b mating = 1 / 4 Grafted with DBA/2 like-sexed skin. Probability of s u s c e p t i b l e genotypes = 1-1/16 F I G . 3 . 3 . M a t i n g system u s e d b y Brambilla et al. ( 1 9 7 0 ) in their analysis of t h e n u m b e r of histocompatibility loci b y w h i c h strains B 6 a n d D B A / 2 differ. d 3 . N u m b e r a n d D i v e r s i t y of H 42 females were m a t e d to D B A / 2 males, and D B A / 2 to give an F I N I sister, and T h e effect the F1N1F1 F x females Loci backcrossed to generation.
Histocompatibility by George D. Snell
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