By Shakir Ali, Scott L. Friedman
ISBN-10: 1578083990
ISBN-13: 9781578083992
This ebook provides state-of-art info summarizing the present realizing of a number of liver ailments, and reports a few key diagnostic and healing advances. The ebook is a set of chosen scientific and clinical themes divided into volumes, every one divided into sections. the 1st quantity treats the mobile, biochemical and immunological mechanisms underlying liver illnesses; the second one specializes in scientific liver ailment pathophysiology and comparable diagnostics and healing insights. it really is was hoping that the objective readers - hepatologists, clinicians, researchers and cademicians - might be uncovered to new rules, and topics past their very own clinical disciplines. furthermore, scholars and all those that desire to magnify their wisdom of advances within the box of liver illnesses will locate this publication an exceptional resource of knowledge.
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Extra resources for Liver Diseases : Biochemical Mechanisms and New Therapeutic (2 Vols)
Example text
2002. Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen α1(I) gene expression in cultured hepatic stellate cells. J Biol Chem 277: 30551-30558. Garcia-Trevijano, E. , Iraburu, M. , DominguezRosales, J. , and Rojkind, M. 1999. Transforming growth factor beta1 induces the 20 LIVER DISEASES expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells. Hepatology 29: 960-970. , and Wisse, E. 1989. In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion.
1997). , 1995). , 1997; Kawabata and Miyazono, 1999). , 2001). The molecular mechanism by which Smad 3 regulates α1(I) collagen gene expression is not known. , 2002). Treatment of HSCs with TGFβ was shown to increase p38 activation and blocking p38 activity inhibited the increase in collagen expression following TGFβ treatment. , 1999). 5. , 1999). , 1997). , 1998). However, the location of the TNFα inhibitory element is not without controversy. One study reported that TNFα inhibited binding of Sp1 to a GC rich region located in the 5' untranslated region of the first exon and that this inhibitory action is responsible for the inhibitory effects of TNFα on collagen gene expression.
J Biol Chem 276: 11041-11048. Goddard, C. , Hoyland, J. , McMahon, R. , Freemont, A. , Haboubi, N. , and Warnes, T. W. 1998. Localisation and semiquantitative assessment of hepatic procollagen mRNA in primary biliary cirrhosis. Gut 43: 433440. , Garrett, L. , and de Crombrugghe, B. 1992. Tissuespecific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells. J Biol Chem 267: 19622-19630. , and Gressner A. M. 1998. Isoforms and splice variant of transforming growth factor beta-binding protein in rat hepatic stellate cells.
Liver Diseases : Biochemical Mechanisms and New Therapeutic (2 Vols) by Shakir Ali, Scott L. Friedman
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