Download Liver regeneration : basic mechanisms, relevant models and by Udayan M. Apte Ph.D. DABT PDF

By Udayan M. Apte Ph.D. DABT

ISBN-10: 0124201288

ISBN-13: 9780124201286

ISBN-10: 0128004312

ISBN-13: 9780128004319

Liver Regeneration: easy Mechanisms, correct types and medical Applications provides state-of-the-art details on liver regeneration study via an built-in, systems-wide viewpoint. The publication addresses discoveries on hepatic progenitor cells, liver regeneration after chemical harm, and liver regeneration as a major treatment for liver failure and disorder.

By addressing the pressing want for translating easy learn findings into clinically correct modalities and power healing functions, the e-book presents the information had to increase liver sufferer administration.

Hundreds of full-color, image pictures and illustrations underline key parts and express researchers and scholars vital facets of liver transplantation, immunofluorescence, and different concepts utilized in liver regeneration.

  • Summarizes present liver regeneration reports and discussions on anticipated discoveries
  • Provides an outline of normal medical and state-of-the-art applied sciences to review liver regeneration
  • Presents info at the molecular mechanisms that impact liver regeneration
  • Highly illustrated, with enormous quantities of full-color, photograph images and illustrations to augment the training procedure

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Extra resources for Liver regeneration : basic mechanisms, relevant models and clinical applications

Sample text

Toxicol Sci 2002;69(2):448–59. 35 [27] Chilakapati J, Shankar K, Korrapati MC, Hill RA, Mehendale HM. Saturation toxicokinetics of thioacetamide: role in initiation of liver injury. Drug Metab Dispos 2005;33(12):1877–85. [28] Mehendale HM. Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol Pathol 2005;33(1):41–51. [29] Mehendale HM. Once initiated, how does toxic tissue injury expand? Trends Pharmacol Sci 2012;33 (4):200–6. [30] Faroon O, Taylor J, Roney N, Fransen ME, Bogaczyk S, Diamond G.

A number of different models have been used to study HPC and are discussed below. METHODS TO ASSESS LIVER REGENERATION 30 2. 1 2-Acetylaminofluorene Combined with Partial Hepatectomy 2-AAF + PH (2-acetylaminofluorene combined with partial hepatectomy) is the classic rat model to study HPC biology. 2-AAF is a mutagen that causes DNA mutations in hepatocytes resulting in development of liver cancers. Whereas 2AAF was associated with liver cancer since the mid-1950s, Emmanuel Farber demonstrated the first use of 2-AAF along with PH to study HPC in late 1970s [137,138].

These include CK-19, A6, OV6, Thy1, and EpCAM that work pretty well in rat tissues [132,140]. Whereas these markers are widely used to detect HPC, significant difference of opinion exists about the choice of the markers used. 2 The DDC Diet Model With the advent of transgenic and knockout mouse technology, a need for a mouse model to study HPC developed mainly because the 2-AFF + PH model could not be established in mice. 01% DDC (3,5diethoxycarbonyl-1,4-dihydrocollidine), which is also called DDTPDC (diethyl 1,4-dihydro2,4,6-trimethyl-3,5- pyridine dicarboxylate) [140,141].

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Liver regeneration : basic mechanisms, relevant models and clinical applications by Udayan M. Apte Ph.D. DABT


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