Download The Truth About the Drug Companies: How They Deceive Us and by Marcia Angell PDF

By Marcia Angell

ISBN-10: 0375508465

ISBN-13: 9780375508462

In the course of her 20 years on the New England magazine of medication, Dr. Marcia Angell had a front-row seat at the appalling spectacle of the pharmaceutical undefined. She watched drug businesses stray from their unique challenge of researching and production necessary medications and as an alternative develop into gigantic advertising machines with extraordinary regulate over their very own fortunes. She observed them achieve approximately unlimited impact over clinical study, schooling, and the way medical professionals do their jobs. She sympathized because the American public, rather the aged, struggled and more and more didn't meet spiraling prescription drug costs. Now, during this daring, hard-hitting new booklet, Dr. Angell exposes the stunning fact of what the pharmaceutical has become–and argues for crucial, long-overdue change.Currently americans spend a spectacular $200 billion every year on prescribed drugs. As Dr. Angell powerfully demonstrates, claims that prime drug costs are essential to fund study and improvement are unfounded: as a matter of fact that drug businesses funnel the majority in their assets into the selling of goods of doubtful profit. in the meantime, as gains leap, the corporations openly use their wealth and gear to push their schedule via Congress, the FDA, and educational scientific centers.Zeroing in on highly winning medications like AZT (the first drug to regard HIV/AIDS), Taxol (the best-selling melanoma drug in history), and the blockbuster hypersensitive reaction drug Claritin, Dr. Angell demonstrates precisely how new items are delivered to marketplace. Drug businesses, she indicates, commonly depend on publicly funded associations for his or her uncomplicated examine; they rig medical trials to make their items glance higher than they're; and so they use their legions of attorneys to stretch out government-granted unique advertising rights for years. additionally they flood the marketplace with copycat medicinal drugs that fee much more than the medication they mimic yet are not any extra effective.The American pharmaceutical has to be stored, customarily from itself, and Dr. Angell proposes a software of important reforms, such as restoring impartiality to medical study and severing the binds among drug businesses and scientific schooling. Written with fierce ardour and substantiated with in-depth learn, the reality in regards to the Drug businesses is a searing indictment of an that has spun uncontrolled.

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The latter have no choice but to spend money on R&D if they wish to be in the pharmaceutical business. They are not investment houses. 50 you can hardly look at the money spent on R&D as money that could have been spent on something else. The Tufts authors say adding opportunity costs is standard accounting practice, and that may be so, but in the context of pharmaceutical R&D, it simply makes no sense. And there is a third problem with the estimate. It is in pretax dollars. But R&D expenses are fully tax deductible.

If the trials are successful, FDA approval follows. Drug companies usually obtain a patent on a new drug before clinical testing begins, because it is difficult to keep information about the drug secret after this point. Patents protect companies against competition during the testing period. But clinical trials usually take a few years, and during that time the drug cannot be sold. That means clinical testing eats into a drug's twenty-year patent life-the time it can be sold without competition.

In 2001, there were about a thousand of them operating around the world, with revenues from their drug company clients of some $7 billion. They establish networks of physicians who, working under the organizations' supervision, are paid to administer the study drugs and collect information on their effects. The number of clinical trials under way in any given year is staggering. 6 In 2001, an estimated 80,000 of them were ongoing in the United States alone. 3 million Americans served as human subjects.

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The Truth About the Drug Companies: How They Deceive Us and What to Do About It by Marcia Angell


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